Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics

Prediction of muscle-invasive bladder cancer using urinary proteomics.

PURPOSE Minimally invasive methods of predicting the risk of muscle-invasive urothelial bladder carcinoma may expedite appropriate therapy and reduce morbidity and cost. EXPERIMENTAL DESIGN Here, capillary electrophoresis coupled mass spectrometry was used to identify urinary polypeptide bladder cancer biomarkers in 127 patients. These markers were used to construct a panel discriminating mus...

Imaging, Diagnosis, Prognosis Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics

Purpose: Minimally invasive methods of predicting the risk of muscle-invasive urothelial bladder carcinoma may expedite appropriate therapy and reduce morbidity and cost. Experimental Design: Here, capillary electrophoresis coupled mass spectrometry was used to identify urinary polypeptide bladder cancer biomarkers in 127 patients. These markers were used to construct a panel discriminating mus...

Nonmuscle-invasive and Muscle-invasive Urinary Bladder Cancer

This study compared the imaging quality, diagnostic accuracy, and apparent diffusion coefficient (ADC) values of reduced field-of-view (rFOV) diffusion-weighted imaging (DWI) and full field-of-view (fFOV) single-shot echo-planar imaging with regard to patients with nonmuscle-invasive or muscle-invasive bladder cancer.Thirty-nine patients with 60 bladder tumors underwent rFOV and fFOV DWI in thi...

Bioinformatics Modeling of Proteomics changes in Muscle Invasive Bladder Cancer

Intra-arterial chemotherapy for muscle-invasive urinary bladder cancer.

A total of 9 patients with muscle-invasive bladder cancer (T3 or T4N0M0) were treated with a modified intra-arterial M-VEC (IA-M-VEC) regimen beginning in October 1992 to evaluate its therapeutic efficacy, and in 3 evaluable patients who subsequently underwent radical cystectomy, the possibility of bladder preservation was assessed. The responses of the 8 evaluable patients were rated as comple...